In a large bowl, combine the buttermilk and hot sauce (if using). Add the chicken thighs, ensuring they are fully submerged. Cover and refrigerate for at least 4 hours or overnight for best flavor.
In a separate bowl, mix the flour, garlic powder, onion powder, paprika, cayenne pepper, salt, and black pepper together.
Heat vegetable oil in a deep skillet or fryer to about 350°F (175°C). You want enough oil to submerge the chicken pieces halfway.
Remove the chicken from the buttermilk and let the excess drip off. Dredge each piece thoroughly in the seasoned flour mixture, ensuring it is well coated. Shake off any excess flour.
Carefully place the breaded chicken in the hot oil, working in batches if necessary. Fry for 12-15 minutes on each side or until golden brown and cooked through (internal temperature should reach 165°F or 74°C).
Once cooked, remove the chicken and place it on a wire rack over a baking sheet to drain excess oil.
Allow the chicken to rest for about 5 minutes before serving, allowing the juices to rediscover.
Notes
Serve on a rustic wooden platter with sprigs of fresh parsley and a side of homemade gravy or creamy mashed potatoes for an inviting, comfort-food appeal.